Herbicidal emulsifiable suspension concentrate compositions

ABSTRACT

There are provided compositions comprising concentrated amount of an herbicidally active agent, or combination of agents, in a solid state suspended in a water immiscible solvent containing an anionic surfactant and a nonionic surfactant and optionally containing an antifoam agent and a suspending or thickening agent. Upon dilution with hard or soft water, said compositions readily form sprayable herbicidal emulsions.

This application is a continuation of application Ser. No. 07/440,179, filed Nov. 22, 1989, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to novel and useful agricultural formulations of herbicidal agents which exhibit poor solubility characteristics in both aqueous and organic media.

Emulsifiable suspension concentrate compositions (or oil flowable dispersions) are compositions which consist essentially of an active agent in a solid state suspended in a non-aqueous liquid containing a surfactant or a mixture of surfactants and said compositions having the property of forming an emulsion when diluted with water.

Emulsifiable suspension concentrate compositions containing pesticides such as herbicides and fungicides as the active agent and paraffinic oils as the non-aqueous liquid are described in European Patent Applications EP-Al-243872 and EP-A2-142670. However, said patent applications do not describe the use of aromatic solvents as the non-aqueous liquid.

Herbicidal agents, such as N-phosphonomethylglycine (glyphosate) and 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (imazapyr), are especially useful for controlling undesirable plant species when applied postemergence. In addition to being highly effective herbicides, said compounds are zwitterionic in nature and generally relatively insoluble in both aqueous and non-aqueous media. Therefore, these types of herbicidal agents are routinely formulated as the corresponding salts as described in European Patent Application EP-A2-220902 and U.S. Pat. No. 4,816,060.

It is an object of this invention to provide an emulsifiable suspension concentrate composition of the free acids of a herbicidal agent, such as N-phosphonomethylglycine and 2-(imidazolin-2-yl)pyridine carboxylic acids, without the preformulation of the corresponding herbicidal salts. It is an object of this invention to produce herbicidal compositions which are physically stable and readily dilutable in hard or soft water to give a sprayable herbicidal emulsion.

SUMMARY OF THE INVENTION

The present invention relates to a novel emulsifiable suspension concentrate composition of a herbicidal agent characterized by a relative degree of insolubility in both aqueous and non-aqueous media. The emulsifiable suspension concentrate composition of the invention is comprised of an active herbicidal agent, or combination of agents, in a solid state suspended in a water immiscible solvent containing an anionic surfactant and a nonionic surfactant and optionally containing an antifoam agent and a suspending or thickening agent.

The water immiscible solvent is a non-paraffinic heavy aromatic solvent consisting of a mixture of aromatic hydrocarbons, such as naphthalenes and alkylnapthalenes, having a distillation range of about 1180° to 3050° C.

The above-described compositions allow the formulation of active herbicidal agents such as amino acids and imidazolinylnicotinic acids without further chemical modifications, such as salt or ester formation. The above compositions provide a stable, concentrated, readily dilutable form of a herbicide suitable for spray application. The compositions also exhibit surprising herbicidal efficacy comparable to the efficacy of the corresponding salts.

DETAILED DESCRIPTION OF THE INVENTION

The present invention also relates to an emulsifiable suspension concentrate composition of a herbicidal agent comprising an amino acid or imidazolinylpyridine carboxylic acid (alone or in combination) in a solid state suspended in a water immiscible liquid containing an anionic surfactant and an ethoxylated fatty acid surfactant and optionally containing an antifoam agent and a thickening or suspending agent.

The herbicidal agent is usually sold in a concentrated form either as a solid or a liquid and, just prior to application, the concentrate is diluted with water, or water containing adjuvants, and sprayed on fields of soil and/or actively growing plants. Solid concentrate formulations, such as granulars, wettable powders and dusts, may also be used.

Since not all solid concentrate formulations of the free acid form of herbicidal agents, such as N-phosphonomethylglycine, exhibit the same high magnitude of efficacy and further since certain highly effective herbicidal compounds, such as N-phosphonomethylglycine and imidazolinyinicotinic acids, are relatively insoluble in water and conventional organic solvents, they are not readily amenable to commercial formulation. Chemical modification of said compounds to give the corresponding salts is required to improve their solubility characteristics. Surprisingly, it has been found that compounds, such as amino acids and imidazolinyinicotinic acids, may be formulated as liquid concentrates without further chemical modifications of said compounds and with a high degree of retention of efficacy.

The emulsifiable suspension concentrate compositions of the present invention are comprised of about 10% to 50% of a herbicidal agent, such as N-phosphonomethylglycine or an imidazolinyinicotinic acid, alone or in combination, suspended in about 29% to 84% of a non-paraffinic aromatic solvent mixture having a distillation range of 118 0 to 3050C containing about 3% to 10% of an anionic surfactant, about 3% to 10% of an ethoxylated fatty acid surfactant, 0 to about 0.10% of an antifoam agent and 0 to about 2.0% of a suspending or thickening agent.

one preferred composition comprises about 30% to 50% of an active herbicidal agent or combination of agents, about 40% to 57% of a non-paraffinic aromatic solvent mixture having a distillation range of 118 0 to 3050C, about 5.0% to 7.09., of an anionic surfacant, about 5.0% to 7.0% of an ethoxylated fatty acid surfactant, about 0.02% to 0.15% of an antifoam agent and 0.5 to 2% of a suspending agent.

Among the herbicidal agents suitable for use in the compositions of the invention are amino acids such as glyphosate and imidazolinylpyridine carboxylic acids such as imazapyr and combinations thereof. A preferred herbicidal agent is glyphosate, alone or in combination with an imidazolinyinicotinic acid.

Solvents suitable for use in the compositions of the invention include heavy aromatic solvent mixtures having a distillation range of 118° to 305° C. Preferred solvents include those mixtures of aromatics having a distillation range of about 183° to 285° C., and the most preferred aromatic solvent mixtures is that which distills in a range of about 225° to 280° C. Anionic surfactants suitable for use in the present invention include alkylarylsulfonic acids such as C₈ -C₁₈ alkylbenzenesulfonic acid, with dodecylbenzenesulfonic acid being the preferred anionic surfactant.

Among the ethoxylated fatty acid surfactants which may be employed are ethoxylated castor oils with about 15-60 ethylene oxide units per molecule. Preferred ethoxylated castor oils are those which have about 36-40 ethylene oxide units per molecule. suitable antifoam agents include silicone polymers containing silica such as dimethylsilicone polymer plus silica, and suitable suspending or thickening agents include hydrated fumed silica or attapulgite clays or amine treated attapulgite clays.

The herbicidal emulsifiable suspension concentrate compositions may be prepared by dissolving an anionic surfactant in an aromatic solvent and adding a solid herbicidal agent or combination of agents, with vigorous agitation to form a suspension. This suspension is milled to the required particle size distribution. A median particle diameter of 1-2 microns provides suitable physical properties. The milled suspension is treated with an ethoxylated fatty acid surfactant and, optionally, an antifoam agent and a suspending or thickening agent and mixed thoroughly. Alternatively, the herbicidal agent is milled as a dry powder and is added to a solution of the anionic surfactant in the aromatic solvent with vigorous agitation to ensure complete dispersion and the remaining components are added with stirring.

The above-prepared emulsifiable suspension concentrate compositions are physically stable and demonstrate excellent dilution properties in hard and soft waters to produce a sprayable herbicidal emulsion. In practice, it is generally preferable to dilute the compositions of the invention in water containing about 0.25% of an adjuvant such as a polyoxyethylene sorbitan laurate surfactant to obtain an especially high degree of herbicidal activity.

In order to facilitate a further understanding of the invention, the following examples are presented primarily for the purpose of illustrating certain more specific details thereof. The invention is not to be deemed limited thereby except as defined in the claims. Unless otherwise noted, all parts are by weight.

EXAMPLE 1 Preparation of an N-phosphonomethylglycine emulsifiable suspension concentrate composition

    ______________________________________                                         Component               %                                                      ______________________________________                                         N-phosphonomethylglycine                                                                               41.90                                                  Dodecylbenzenesulfonic acid                                                                            6.00                                                   Ethoxylated castor oil, 36C.sup.1                                                                      6.00                                                   Dimethylsilicone polymer with silica.sup.2                                                             0.10                                                   Mixture of aromatic hydrocarbons with                                                                  46.00                                                  a distillation range of 226°-279° C..sup.3                                               100.00                                                 ______________________________________                                          .sup.1 36 units of ethylene oxide per molecule Flomo ® 36C,                manufactured by DeSoto                                                         .sup.2 TH 100IND ® antifoam, manufactured by ThompsonHayward               .sup.3 Aromatic 200 ®, manufactured by EXXON                         

METHD 1

An anionic surfactant, dodecylbenzenesulfonic acid, is dissolved in a water immiscible solvent, Aromatic 200®, with stirring. This solution is treated with the herbicidal agent, N-phosphonomethylglycine, in a crystalline or powder state with vigorous stirring to give a dispersion. The resultant dispersion is milled until a median particle size of 1-2 microns is obtained.

The milled dispersion is treated with an ethoxylated fatty acid surfactant, castor oil, 36C¹, and an antifoam agent, dimethylsilicone polymer with silica² and mixed thoroughly.

Method 2

The herbicidal agent, N-phosphonomethylglycine, is milled to give a median particle size of 1-2 microns and then added to a solution of an anionic surfactant, dodecylbenzenesulfonic acid in a water immiscible solvent, Aromatic 200®, with vigorous agitation. The resultant dispersion is treated with an ethoxylated fatty acid surfactant, castor oil, 36C¹, and an antifoam agent, dimethylsilicone polymer plus silica², and mixed thoroughly.

Physical Properties

The physical characteristics of the above-described N-phosphonomethylglycine emulsifiable concentrate composition are shown below.

    ______________________________________                                         Viscosity (Brookfield LVT at 22° C.                                                            500-600 cP                                              spindle #2, speed 30 rpm)                                                      Density at 20° C.                                                                              1.41 g/mL                                               Particle size (Horiba CAPA 700)                                                                       1.21 microns                                                                   (median)                                                pH, 2% diluted in deionized water                                                                     2.0-2.4                                                 Dispersibility in water (in both                                                                      Good emulsifica-                                        standard hard and soft waters),                                                                       tion, no oil sep-                                       2.5 g in 100 ml total volume.                                                                         aration after 24                                                               hours.                                                  ______________________________________                                    

EXAMPLE 2 Preparation of 2-(imidazolin-2-yl)nicotinic acid emulsifiable suspension concentrate compositions

    ______________________________________                                         Components            A       B                                                ______________________________________                                         Imazethapyr           --      33.3                                             Imazapyr              33.33   --                                               Dodecylbenzenesulfonic acid                                                                          5.00    5.00                                             Ethoxylated castor oil, 36C.sup.1                                                                    5.00    5.00                                             Dimethylsilicone polymer with                                                                        0.03    0.03                                             silica.sup.2                                                                   Mixture of aromatic hydrocarbons                                                                     56.64   56.64                                            with a distillation range of                                                   226°-279° C.                                                                                   100.00                                           ______________________________________                                          .sup.1 36 units of ethylene oxide per molecule Flomo ® 36C,                manufactured by DeSoto                                                         .sup.2 TH IND30 ® antifoam, manufactured by ThompsonHayward                .sup.3 Aromatic 200 ®, manufactured by EXXON                         

Method

The herbicidal agent, as a finely divided powder, is added to a rapidly stirred solution of the anionic surfactant, dodecylbenzenesulfonic acid, in the aromatic solvent, Armomatic 200®. The resultant dispersion is treated with the remaining components and placed on a high shear mixer for 3 minutes.

Optionally the solid herbicidal agent is milled to a median particle size of 1-2 microns prior to use in the above-described preparation.

    ______________________________________                                         Physical Properties                                                                             A           B                                                 ______________________________________                                         Dispersibility in water,                                                                        Good emulsi-                                                                               Good emulsi-                                      4.0 g in 100 ml total                                                                           fication,   fication,                                         volume.          slight settl-                                                                              slight settl-                                                      ing after 24                                                                               ing after 24                                                       hours, easily                                                                              hours, easily                                                      resuspended resuspended                                       ______________________________________                                    

EXAMPLE 3 Preparation of combination emulsifiable suspension concentrate compositions

    ______________________________________                                         Components          C       D                                                  ______________________________________                                         Glyphosate          37.69   32.89                                              Imazapyr            4.20    9.00                                               Dodecylbenesulfonic acid                                                                           6.00    6.00                                               Flomo ® 36C.sup.1                                                                              6.00    6.00                                               TH 100IND ® antifoam.sup.1                                                                     0.10    0.10                                               Aromatic 200 ®.sup.1                                                                           46.01   46.01                                                                  100.00  100.00                                             ______________________________________                                          .sup.1 As described in Example 1.                                        

Method

A solution of dodecylbenzene in Aromatic 200® is treated with glyphosate with rapid stirring. The resultant dispersion is treated with the remaining components and placed on a high shear mixer for 3 minutes.

Optionally, a dispersion of glyphosate and the imidazolinylnicotinic acid solid in a solution of dodecylbenzenesulfonic acid in Aromatic 200®is milled to give a median particle size of 1-2 microns prior to the addition of the remaining components.

    ______________________________________                                         Physical Properties                                                                             C           D                                                 ______________________________________                                         Dispersibility in water,                                                                        Good emulsi-                                                                               Good emulsi-                                      4.0 g in 100 ml total                                                                           fication,   fication,                                         volume.          slight oil  slight oil                                                         separation  separation                                                         after 24    after 24                                                           hours, easily                                                                              hours, easily                                                      resuspended resuspended                                       ______________________________________                                    

EXAMPLE 4 Greenhouse Postemergent Herbicidal Evaluation

This is an evaluation of the postemergent herbicidal activity of the emulsifiable suspension concentrate composition of N-phosphonomethylglycine as compared to a commercial aqueous solution composition of the isopropylammonium salt of N-phosphonomethylglycine.

The test compositions used for this evaluation are the emulsifiable suspension concentrate composition of N-phosphonomethylglycine which is described in Example 1 and referred to herein as Glyphosate 40 ESC and an aqueous soluble composition of the isopropylammonium salt of N-phosphonomethylglycine which is commercially sold by Monsanto under the trademark ROUNDUP® and referred to herein as Glyphosate Salt.

Seedling plants are grown in jiffy flats for about 2 weeks. The glyphosate 40 ESC composition is dispersed in water containing 0.25% TWEEN-20® a polyoxyethylene sorbitan monolaurate surfactant manufactured by Atlas Chemical Industries in sufficient quantity to provide the equivalent of about 0.063 kg to 0.500 kg per hectare of N-phosphonomethylglycine to the plants when applied through a spray nozzle operating at 40 psi for a predetermined time. The Glysphosate Salt is dispersed in water according to the label directions and applied to the plants as described above. After spraying, the plants are placed on greenhouse benches and cared for in the usual manner commensurate with conventional greenhouse practices. The plants are evaluated at 7 and 14 days after treatment and rated according to the rating system shown below.

    ______________________________________                                         Rating System      % Control                                                   ______________________________________                                         No effect           0                                                          Possible effect     1-10                                                       Slight effect      11-25                                                       Moderate effect    26-40                                                       Definite injury    41-60                                                       Herbicidal effect  61-75                                                       Good Herbicidal effect                                                                            76-90                                                       Approaching complete kill                                                                         91-99                                                       Complete kill      100                                                         ______________________________________                                         Plant Species Used                                                             Common Name      Scientific Name                                               ______________________________________                                         Mustard Wild     Brassica kaber                                                Cotton           Gossypium hirsustum                                           Corn             Zea mays                                                      Morningglory     Ipomoea purpurea                                              Soybean          Glycine max                                                   Barnyard Grass   Echinochloa crus-galli                                        Lambsquaters     Chenopidium album                                             Ragweed          Ambrosia artemisifolia                                        Green Foxtail    Setaria veridis                                               ______________________________________                                    

The data obtained at 14 days after treatment are reported in Table I below.

                                      TABLE I                                      __________________________________________________________________________     Postemergence Herbicidal Evaluation                                                                                       Grn                                          Rate Must-                                                                              Cot-                                                                              Field                                                                             Morn-                                                                              Soy-                                                                              Barn-                                                                              Lambs-                                                                             Rag-                                                                               Fox-                                Composition                                                                             (kg/ha)                                                                             ard ton                                                                               Corn                                                                              glry                                                                               bean                                                                              yardg                                                                              quart                                                                              weed                                                                               tail                                __________________________________________________________________________     Glyphosate Salt                                                                         0.500                                                                               80.0                                                                               80.0                                                                              90.0                                                                              66.7                                                                               78.3                                                                              98.7                                                                               99.3                                                                               38.3                                                                               100.0                               Glyphosate ESC                                                                          0.500                                                                               60.0                                                                               50.0                                                                              95.0                                                                              71.7                                                                               80.0                                                                              94.3                                                                               96.3                                                                               40.0                                                                               91.7                                Glyphosate Salt                                                                         0.250                                                                               38.3                                                                               35.0                                                                              58.3                                                                              63.3                                                                               63.3                                                                              71.0                                                                               83.3                                                                               33.3                                                                               85.0                                Glyphosate ESC                                                                          0.250                                                                               33.3                                                                               40.0                                                                              85.3                                                                              75.3                                                                               71.7                                                                              78.3                                                                               100.0                                                                              53.3                                                                               93.3                                Glyphosate Salt                                                                         0.125                                                                               13.3                                                                               20.0                                                                              18.3                                                                              30.0                                                                               20.0                                                                              23.3                                                                               61.7                                                                                6.7                                                                               46.7                                Glyphosate ESC                                                                          0.125                                                                               26.7                                                                                3.3                                                                              71.7                                                                              30.0                                                                               50.0                                                                              48.3                                                                               83.3                                                                               23.3                                                                               81.7                                Glyphosate Salt                                                                         0.063                                                                                0.0                                                                                3.3                                                                               3.3                                                                              15.0                                                                                6.7                                                                              16.7                                                                               36.7                                                                                0.0                                                                               20.0                                Glyphosate ESC                                                                          0.063                                                                                6.7                                                                                0.0                                                                              61.7                                                                              10.0                                                                               20.0                                                                              35.0                                                                               70.0                                                                               13.3                                                                               40.0                                __________________________________________________________________________

EXAMPLE 5 Field Postemergent Herbicidal Evaluation

The test compositions used are Glyposate 40 ESC and Glyphosate Salt, and are as described in Example 4.

A field containing established, actively growing plants is divided into plots of 10 meters x 30 meters and is sprayed with a tractor mounted compressed air sprayer with a delivery of 200 liters per hectare. The Glyphosate 40 ESC composition is dispersed in water containing 0.25% TWEEN-20® in sufficient quantity to provide the equivalent of 2.0 kg to 0.5 kg per hectare to the plants. Glyphosate Salt is dispersed in water according to the label directions and applied to the plants as described hereinabove. The plots are evaluated at 7 and 14 days after treatment. Each treatment is replicated once. The data obtained for 14 days after treatment is reported in Table II.

    ______________________________________                                         Plant Species                                                                  Common Name        Scientific Name                                             ______________________________________                                         Redroot pigweed    Amoranthus retroflexus                                      Common lambsquarters                                                                              Chenopodium album                                           Common purslore    Portulara oleracea                                          Common ragweed     Ambrosia artemisiifola                                      Large crabgrass    Digitaria sanguiralis                                       Fall panicum       Panicum diclotomiflorum                                     Barnyard grass     Echirochloa crus-gelli                                      Foxtail millet     Setaria italica                                             ______________________________________                                    

                                      TABLE II                                     __________________________________________________________________________     Postemergence Field Evaluation                                                               Red                                                                            Root                  Fox-                                                Rate Pig-                                                                              Lambs-                                                                             Rag-                                                                               Crab-                                                                              Fall-                                                                             Barn-                                                                              tail                                       Composition                                                                             kg/ha                                                                               weed                                                                              quart                                                                              weed                                                                               gras                                                                               pani                                                                              yardg                                                                              millet                                     __________________________________________________________________________     Glyphosate Salt                                                                         0.5  100                                                                                80  98 100  95                                                                               100 100                                        Glyphosate ESC                                                                          0.5  100                                                                               100  85 100  98                                                                               100 100                                        Glyphosate Salt                                                                         1.0  100                                                                               100 100 100 100                                                                               100 100                                        Glyphosate ESC                                                                          1.0  100                                                                               100 100 100 100                                                                               100 100                                        Glyphosate Salt                                                                         2.0  100                                                                               100 100 100 100                                                                               100 100                                        Glyphosate ESC                                                                          2.0  100                                                                               100 100 100 100                                                                               100 100                                        __________________________________________________________________________ 

I claim:
 1. A suspension concentrate composition of a herbicidal agent which comprises N-phosphonomethylglycine, an aromatic hydrocarbon mixture having a distillation range of about 118° C. to 305° C., a C₈ -C₁₈ alkylbenzenesulfonic acid and an ethoxylated castor oil with 15-60 ethylene oxide units per molecule.
 2. The composition according to claim 1 wherein the aromatic hydrocarbon mixture has a distillation range of about 183° C. to 285° C., the C₈ -C₁₈ alkylbenzenesulfonic acid is dodecylbenzenesulfonic acid and the ethoxylated castor oil has 36-40 ethylene oxide units per molecule.
 3. A suspension concentrate which comprises about 10.0% to 50.0% of N-phosphonomethylglycine, about 29.0% to 84.0% of an aromatic hydrocarbon mixture having a distillation range of about 183° C. to 285° C., about 3.0% to 10.0% of dodecylbenzenesulfonic acid, about 3.0% to 10.0% ethoxylated castor oil with 36 ethylene oxide units per molecule, 0 to about 0.10% of an antifoam agent and 0 to about 2.0 % of a suspension agent.
 4. The composition according to claim 3 comprising about 40.0% to 45.0% of N-phosphonomethylglycine, about 45.0% to 47.0% of an aromatic hydrocarbon mixture having a distillation range of about 225° C. to 280° C., about 5.0% to 7.0% of ethoxylated castor oil having 36 units of ethylene oxide per molecule and about 0.05% to 0.15% of an antifoam agent.
 5. The composition according to claim 1 further comprising an antifoam agent or a suspension agent. 